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YCR annual science meeting

YCR Annual Science Meeting 2006
University of York
Tuesday 27 June

Programme

Please note that to attend this event you must have registered in advance by the closing date. You cannot register on the day.

8.45am	Registration and Coffee
9.30am	Welcome Professor E A Dawes (Chairman, Scientific Advisory Committee)
9.35am	Open Papers - Scientific Session 1
10.35am	Coffee, Poster Session and Scientific Exhibition
11.05am	Open Papers - Scientific Session 2
12.05pm	Buffet Lunch and Scientific Exhibition
1pm	Poster viewing
2pm	Open Papers - Scientific Session3
3.15pm	Tea, Poster Session & Scientific Exhibition
3.45pm	Tracking the Natural History of Childhood Leukaemia Professor Melvyn F Greaves FRS (The Institute of Cancer Research, London)
4.45pm	Announcement of Poster Award
4.50pm	Closing address Professor E A Dawes (Chairman, Scientific Advisory Committee)

Scientific presentations to be 15 minutes duration and the Guest Lecture is 1 hour including questions.

The Open Papers and Guest Lecture will be held in the
Lecture Theatre K018, Biology Department.

The Poster presentations are in Rooms M052 & M049 Refreshments and Scientific Exhibition will be held in the Atrium in the Biology Department (adjacent to the Lecture Theatre).

Please stand by your Posters from 1pm to 2pm and remove them from the stands at the end of the afternoon Poster Session.

Organising Committee:
Professor E A Dawes
Dr G E Blair
Professor A Hanby
Dr V Speirs

This meeting was sponsored by:
Ambion Europe Ltd
Corbett Research Ltd
Eppendorf UK Ltd
Fisher Scientific
Harlan UK
LGC Promochem
Merck Bioscience Ltd
Perbio Sciences UK Ltd
Qiagen Ltd
Roche Diagnostics Ltd
Starlab (UK) Ltd
Thistle Scientific Ltd

	OPEN PAPERS - SCIENTIFIC SESSION 1 Chair:ProfessorA Hanby
9.35am	DEVELOPMENT OF PRODRUGS SELECTIVELY ACTIVATED BY TUMOUR EXPRESSED CYTOCHROMES P450 K Pors, M Sutherland, N Harris, P M Loadman and L H Patterson Institute of Cancer Therapeutics, University of Bradford, West Yorkshire BD7 3AY
9.50am	EOADJUVANT CHEMOTHERAPY IN BREAST CANCER: CAN QUANTITATIVE MAGNETIC RESONANCE IMAGING AND SPECTROSCOPY HELP TO PREDICT POST-SURGERY DISEASE-FREE SURVIVAL? David J Manton, Amulya Chaturvedi, Anne Hubbard, Michael J Lind, Martin Lowry, Anthony Maraveyas, Martin D Pickles and Lindsay W Turnbull. The Postgraduate Medical Institute of the University of Hull, Division of Cancer, in association with the Hull York Medical School, The University of Hull. *Hull and East Yorkshire Hospitals NHS Trust.
10.05am	DO DIFFUSION CHANGES PRECEDE SIZE ALTERATIONS IN BREAST TUMOURS UNDERGOING NEOADJUVANT CHEMOTHERAPY? M D Pickles, P Gibbs, M Lowry and L W Turnbull Centre for Magnetic Resonance Investigations, University of Hull
10.20am	HOW GOOD IS FDG DUAL-HEADED PET FOR IDENTIFYING SURGICAL SUITABILITY OF PATIENTS WITH NON-SMALL CELL LUNG CANCER? W B Tindale, E Lorenz,M B Hanney, S Matthews, R Vaughan, S Mitchell, S Fleming, A Connolly, E J R Van Beek. Sheffield Teaching Hospitals NHS Foundation Trust. Open Papers 1
10.35am	COFFEE, POSTER SESSION AND SCIENTIFIC EXHIBITION OPEN PAPERS - SCIENTIFIC SESSION 2 Chair:Dr G E Blair
11.05am	FUNCTIONAL SIGNIFICANCE OF ALTERED PROSTAGLANDIN-SIGNALLING IN HORMONE RESISTANT BREAST CANCER M Cummings andV Speirs Pathology & Tumour Biology, Leeds Institute for Molecular Medicine, JIF Building, St James's University Hospital, Leeds LS9 7TF
11.20am	THE ROLE OF OSTEOPROTEGERIN ON PROSTATE CANCERCELL SURVIVAL NA Cross, N Jokonya, I Holen, FC Hamdy, CL Eaton Academic Unit of Urology, University of Sheffield

11.35am	GLOBAL GENE EXPRESSION ANALYSIS TO IDENTIFY GENES INVOLVED IN ANDROGEN RECEPTOR SIGNALLING AND REGULATION OF HUMAN PROSTATIC STEM CELLS PA Berry, SD Bryce, MJ Stower¹, NJ Maitland and AT Collins YCR Cancer Research Unit, Department of Biology, University of York, York, YO10 5DD ¹Department of Urology, York District Hospital Trust, York
11.50am	MCPH1, A POTENTIAL PREDICTOR FOR RESPONSE TO CANCER CHEMOTHERAPY Sandra Bell, Abeer Shaaban, Clare Walker, Valerie Speirs & Ewan Morrison Leeds Institute for Molecular Medicine, JIF Building, St James's University Hospital, Leeds, LS9 7TF Open Papers 2
12.05pm	BUFFET LUNCH AND SCIENTIFIC EXHIBITION
1pm	POSTER VIEWING Posters OPEN PAPERS - SCIENTIFIC SESSION 3 Chair: Dr V Speirs
2pm	NUCLEOTIDE EXCISION REPAIR IS CONTROLLED BY UBIQUITINATION, THROUGH PHOSPHORYLATION OF THE E1 UBIQUITIN-ACTIVATING ENZYME Thierry Nouspikel Institute for Cancer Studies, University of Sheffield
2.15pm	RPA IS REQUIRED FOR MAMMALIAN HOMOLOGOUS RECOMBINATION REPAIR Kate Sleeth and Thomas Helleday Institute of Cancer Studies, University of Sheffield
2.30pm	CANCER-ASSOCIATED MIS-SPLICING OF THE DNA REPLICATION PROTEIN Ciz1 Faisal Abdel Rahman, Justin F-X Ainscough, Nikki Copeland and Dawn Coverley Biology Department, University of York, Heslington, York, Y010 5YW Heart Research Centre and CRISTAL, Leeds University, UK, LS2 9JT
2.45pm	OSS OF ONE P53 ALLELE RESULTS IN FOUR-FOLD REDUCTION OF P53 mRNA AND PROTEIN: A BASIS FOR P53 HAPLO-INSUFFICIENCY Cian Lynch and Jo Milner Yorkshire Cancer Research P53 Group, Department of Biology, University of York, York, YO10 5DD
3pm	PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF HUMAN HAEMOPOIETIC CELL POPULATIONS WITH HIGH STEM CELL ACTIVITY S A Boxall¹, G P Cook¹, D Pearce², D Bonnet² and E A de Wynter¹ ¹Leeds Institute of Molecular Medicine, St James's University Hospital, Leeds. ²Haemopoietic Stem Cell Laboratory, Cancer Research UK, London
3.15pm	TEA, POSTER SESSION AND SCIENTIFIC EXHIBITION
3.45pm	TRACKING THE NATURAL HISTORY OF CHILDHOOD LEUKAEMIA Professor Melvyn F Greaves FRS, Chairman, Section of Haematological Oncology, Institute of Cancer Research, Chester Beatty Laboratories, London. Introduced by Professor E A Dawes Open Papers 3
4.45pm	ANNOUNCEMENT OF POSTER AWARD
4.50pm	CLOSING ADDRESS Professor E A Dawes

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