RESEARCH

Directly or indirectly, cancer will touch everyone's lives. There is no greater or more worthwhile challenge than the ongoing battle to develop and improve anti-cancer treatments, for everyone's sake.

programme of research


UNIVERSITY OF BRADFORD

2005/6

Institute of Cancer Therapeutics
Director: Professor L.H. Patterson


L.H. Patterson
R.A. Falconer
K. Pors
C. W. Sutton

Design, synthesis and antitumour selectivity of peptide conjugates as metalloproteinase -activated delivery devices .

Design, synthesis and pharmacology of unnatural sugars developed as inhibitors of tumour-expressed polysialyltransferases.

Design, synthesis and biological evaluation of spirocyclopropacyclohexadienones as specific substrates for tumour-expressed cytochrome P450s.

Design, synthesis and biological evaluation of tumour hypoxia-selective azaheterocyclic-N-oxides.



Project Ref B205

L.H. Patterson
C. Sutton

Development of mass spectrometry-based proteomic analysis of cytochromes P450 to aid target validation and drug discovery.

Development of mass spectrometry-based proteomic analysis of tumour and stromal matrix metalloproteinases to aid target validation and drug discovery.