programme of research

UNIVERSITY OF BRADFORD

2006/7

Institute of Cancer Therapeutics

Director: Professor L.H. Patterson

L. H. Patterson
K. Afarinkia
R. A. Falconer
K. Pors

Design, synthesis and antitumour selectivity of peptide conjugates as metalloproteinase -activated delivery devices
Design, synthesis and pharmacology of unnatural sugars developed as inhibitors of tumour expressed polysialyltransferases

Design and synthesis of Golgi mannosidase II inhibitors

Design, synthesis and biological evaluation of chloromethylindolines as specific substrates for tumour expressed cytochrome P450s.

Design, synthesis and biological evaluation of tumour hypoxia-selective azaheterocyclic -N-oxides

L. H. Patterson
C. W. Sutton

Development of mass spectrometry-based proteomic analysis
of cytochromes P450 to aid target validation and drug discovery.

Development of mass spectrometry-based proteomic analysis of tumour and stromal matrix metalloproteinases to aid target validation and drug discovery.