research publications

University of Bradford

2001/2

Yorkshire Cancer Research Laboratory of Drug Design
The Tom Connors Cancer Research Centre
Director: Professor T.C. Jenkins

Gregson, S.J., Howard, P.W., Hartley, J.A., Brooks, N.A., Adams, L.J., Jenkins, T.C., Kelland, L.R. and Thurston, D.E. (2001)
Design, synthesis, and evaluation of a novel pyrrolobenzodiazepine DNA-interactive agent with highly efficient cross-linking ability and potent cytotoxicity.
Journal of Medicinal Chemistry 44, 737-748.

Haq, I., Chowdhry, B.Z. and Jenkins, T.C. (2001)
Calorimetric techniques in the study of high-order DNA-drug interactions.
Methods in Enzymology 340, 109-149.

Perry, P.J. and Jenkins, T.C. (2001)
DNA tetraplex-binding drugs: structure-selective targeting is critical for antitumour telomerase inhibition.
Mini Reviews in Medicinal Chemistry 1, 31-41.

Lane, A.N. and Jenkins, T.C. (2001)
Structures and properties of multi-stranded nucleic acids.
Current Organic Chemistry 5, 845-869.

Skelly, J.V., Knox, R.J. and Jenkins, T.C. (2001)
Aerobic nitroreduction by flavoproteins: enzyme structure, mechanisms and role in cancer chemotherapy.
Mini Reviews in Medicinal Chemistry 1, 293-306.

Gregson, S.J., Howard, P.W., Corcoran, K.E., Jenkins, T.C., Kelland, L.R. and Thurston, D.E. (2001)
Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1 c][1,4]benzodiazepine dimer.

Bioorganic Medicinal Chemistry Letters 11, 2859-2862.

Perry, P.J., Arnold, J.R.P. and Jenkins, T.C. (2001)
Telomerase inhibitors for the treatment of cancer: the current perspective.
Expert Opinion on Investigational Drugs 10, 2141-2156.