research publications

University of Leeds

2002/3

Research School of Medicine, Dentistry, Psychology and Health
Dean of Research: Professor M.A. Smith

Askham, J.M., Vaughan, K.T., Goodson H.V. and Morrison, E.E. (2002)
Evidence that an Interaction between EB1 and p150^Glued  is required for the Formation and Maintenance of a Radial Microtubule Array Anchored at the Centrosome.
Molecular Biology of the Cell 13, 3627-3645.

Morrison, E.E., Moncur P.M. and Askham, J.M. (2002)
EB1 identifies sites of microtubule polymerisation during neurite development.
Molecular Brain Research 98, 145-152.

Achuthan, R., Bell, S.M., Carr, I., Leek, J., Roberts, P., Horgan, K., Markham, A.F., Selby, P.J. and MacLennan, K.A. (2002)
BCL10 in malignant lymphomas - an evaluation using fluorescence in situ hybridization.
Journal of Pathology 196(1), 59-66.

Achuthan, R., Carr, I.M., Leek, J.P., Hodge, D., Bell, S.M., Roberts, P., Horgan, K., Bonthron, D.T., Selby, P.J., Markham, A.F. and MacLennan, K.A. (2003)
Detection by fluorescence in situ hybridization of microdeletions at 1p36 in lymphomas, unidentified on cytogenetic analysis. 
Cancer Genetics and Cytogenetics 142, 46-50.

Tagoh, H., Himes, R., Clarke, D.,Leenen, P., Riggs, A.D., Hume, D. and Bonifer, C. (2002)
Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during the differentiation of purified early myeloid precursor cells into activated macrophages.
Genes & Development 16, 1721 - 1737

Chapple, K.S., Scott, N., Guillou, P.J., Coletta, P.L. and Hull, M.A. (2002)
Interstitial cell cyclooxygenase-2 expression is associated with increased angiogenesis in human sporadic colorectal adenomas.
Journal of Pathology 198, 435-441

Ko, S.C.W., Chapple, K.S., Hawcroft, G., Coletta P.L., Markham A.F. and Hull, M.A. (2002)
Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells.
Oncogene 21, 7175-7186.

Chapple, K.S., Scott, N., Guillou, P.J., Coletta, P.L. and Hull, M.A. (2002)
Analysis of cyclooxygenase expression in human colorectal adenomas.
Diseases of the colon and rectum 45, 1316-1324.

Court, M., Robinson, P.A., Dixon, M.F. and Crabtree, J.E. (2002).
Gastric Helicobacter infection in murine and gerbil models: comparative analysis of effects of H. pylori and H. felis on gastric epithelial cell proliferation.
Journal of Infectious Diseases 186, 1348-1352.

Wallasch, C., Crabtree, J.E., Bevac, D., Robinson, P.A., Wagner, H. and Ullrich, A.  (2002)
Helicobacter pylori stimulated EGF receptor transactivation in gastric epithelial cells requires metalloprotease cleavage of HB-EGF.
Biochemical and Biophysical Research Communications  295, 695-701

Dzierianowska-Fangrat, K., Crabtree, J.E., Rozynek, E., Durra, W., Celinska-Cedro, D., Wojda, U. and Dzierzanowska, D.(2002) 
Helicobacter pylori cagA genotype and density of colonisation in relation to gastric inflammation in children.
European Journal of Gastroenterology and Hepatology 14, 1303-1307.

Felley, C.P., Pignatelli, B., van Melle, G.D., Crabtree, J.E., Stolte, M., Dieze, J., Corthesy-Theulaz, I., Michetti, P., Bancel, B., Patricot, L.M., Ohshima, H. and Felley-Basco, E.  (2002)
Oxidative stress in gastric mucosa of asymptomatic humans infected with Helicobacter pylori: effect of bacterial eradication.
Helicobacter 7, 342-348.

Wu, A.H., Crabtree, J.E., Bernstein, L., Hawtin, P., Cockburn, M., Tseng, C.C. and Forman, D. (2003)
Role of Helicobacter pylori CagA+ strains and risk of adenocarcinoma of the stomach and the esophagus.
International Journal of Cancer 103, 815 - 821.

Hawcroft, G., Gardner, S.H., and Hull, M.A.  (2003)
Activation of peroxisome proliferator-activated receptor ã does not explain the anti-proliferative activity of the non-steroidal anti-inflammatory drug indomethacin on human colorectal cancer cells.
Journal of Pharmacology and Experimental Therapeutics, Fast Forward, DOI:10.1124/jpet.103.048769.

Barratt, P.L., Seymour, M.T., Stenning, S.P., Georgiades, I., Walker, C., Birbeck, K., Quirke, P., and the UKCCCR AXIS trial collaborators (2002)
DNA markers predicting benefit from adjuvant fluorouracil in patients with colon cancer: a molecular study.
Lancet 360, 1381-91

Adlard, J.W., Richman, S.D., Seymour, M.T., Quirke, P. (2002)
Prediction of response of colorectal cancer to systematic therapy.
Lancet Oncology 3, 75-82

Skliris, G.P., Parkes, A.T., Limer, J.L., Burdall, S.E., Carder, P.J. and Speirs, V. (2002)
Evaluation of seven oestrogen receptor ??antibodies for immunohistochemistry, Western blotting and flow cytometry in human breast tissue.
Journal of Pathology 197, 155-162.

Parkes, A.T. and Speirs, V. (2002)
Meeting Report: British Cancer Research Meeting 2002.
Breast Cancer Research 4, 202-204.

Speirs, V., Skliris, G.P., Burdall, S.E. and Carder, P.J.
Distinct expression patterns of ER? and ER? in normal human mammary gland.
Journal of Clinical Pathology 55, 371-374.

Rawstron, A.C., Yuille, M.R., Fuller, J., Cullen, M., Kennedy, B., Richards, S.J., Jack, A.S., Matutes, E., Catovsky, D., Hillmen, P. and Houlston, R.S. (2002)
Inherited predisposition to CLL is detectable as sub-clinical monoclonal B-lymphocyte expansion.
Blood 100, 2289-2290.

Rawstron, A.C., Green, M.J., Kuzmicki, A., Kennedy, B., Fenton, J.A.L., Evans, P.A.S., O'Connor, S.J.M., Richards, S.J., Morgan, G.J., Jack, A.S. and Hillmen, P. (2002)
Monoclonal B lymphocytes with the characteristics of "indolent" chronic lymphocytic leukemia are present in 3.5% of adults with normal blood counts.
Blood 100, 635-639.

Faculty of Biological Sciences
(School of Biochemistry and Molecular Biology)
Chairman of Faculty:  Professor K.T. Holland
Head of the School:  Professor A.J. Turner

Usmani, B.A., Harden, B., Maitland, N.J. and Turner, A.J. (2002)
Differential expression of neutral endopeptidase-24.11 (neprilysin) and endothelin-converting enzyme in human prostate cancer cell lines.
Clinical Science (London, England: 1979) 103, 314S-317S

Hall, K.T., Giles, M.S., Calderwood, M.A., Goodwin, D.J., Matthews, D.A. and  Whitehouse, A. (2002)
The Herpesvirus saimiri ORF 73 gene product interacts with the cellular protein p32.
Journal of Virology 76, 11612-11622.

Fox, E.J., Wright, S.C. (2003)
The transcriptional repressor gene Mad3 is a novel target for regulation by E2F1.
Biochem J. 2003 Feb 15; 370:307-13.

Kime L., Wright S.C. (2003)
Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc.
Biochem J.  Feb 15; 370:291-8.

Yorkshire Cancer Research Photodynamic Therapy Group
Centre for Photobiology and Photodynamic Therapy
Principal Investigator:  Professor S B Brown

Taylor, E. L. and Brown, S. B. (2002)
The advantages of aminolevulinic acid photodynamic therapy in dermatology
Journal of Dermatological Treatment 13 (Suppl 1), S3-S11.

Mellish, K. J., Cox, R. D., Vernon D. I., Griffiths, J. and Brown, S. B. (2002)
In vitro photodynamic activity of a series of methylene blue analogues
Photochemistry and Photobiology 75, 392-397

Akker, J. T. H. M. van den and Brown, S. B. (2002)
Photodynamic therapy based on 5-aminolevulinic acid: applications in dermatology
Photobiology for the 21st Century, T. P. Coohill and D. P Valenzeno, eds, 13th International Congress on Photobiology, 165-181.

Tunstall, R. G., Barnett, A. A., Schofield, J., Griffiths, J., Vernon, D. I., Brown, S. B. and Roberts, D. J. H. (2002)
Porphyrin accumulation induced by 5-aminolaevulinic acid esters in tumour cells growing in vitro and in vivo
British Journal of Cancer 87, 246-250.