RESEARCH

Directly or indirectly, cancer will touch everyone's lives. There is no greater or more worthwhile challenge than the ongoing battle to develop and improve anti-cancer treatments, for everyone's sake.

programme of research


University of Hull

2002/3

Centre for Magnetic Resonance Investigations
Scientific Director: Professor L W Turnbull


M. Lowry
D. Manton
P. Gibbs
C. Tan
L.W. Turnbull
Early prediction of the response of locally advanced primary breast cancer to neoadjuvant chemotherapy by dynamic MR imaging, measurement of the apparent diffusion coefficient of water and proton spectroscopy.

Determination of the overall response of locally advanced primary breast cancer to neoadjuvant chemotherapy by DCE-MRI, compared to conventional imaging and definitive histopathology.



P. Kneeshaw
M. Lowry
L.W. Turnbull
Determination of role of MRI in classification of disease in patients with indeterminate mammographically detected micro calcification.

Comparison of extent and grade of DCIS determined by X-ray mammography, ultrasound, MRI and histopathology and correlation with immunohistochemical markers of neoangiogenesis.



L.W. Turnbull
Determination of the comparative effectiveness of MR imaging in women with biopsy proven primary breast cancer scheduled for wide local excision.



P. Kneeshaw
L.W. Turnbull
Comparison of the effectiveness of loco-regional staging of patients with primary lobular breast cancer.



M. Lowry
D. Manton
L.W. Turnbull
Effect of conventional hormone replacement therapy and a specific oestrogen receptor modulator on breast parenchymal volume and contrast uptake characteristics.



P. Gibbs
L.W.Turnbull
Use of textural analysis of contrast enhanced images to improve breast lesion characterization.



P. Kneeshaw
L.W. Turnbull
Assessment of change in clinical management of patients with locally advanced primary breast cancer following DCE-MRI.


P. Gibbs
P. Kneeshaw
L.W. Turnbull
Role of MR imaging in intensity modulated radiotherapy planning of primary prostatic malignancy, with particular reference to prostate movement and tumour localization by ADC and DCE-MRI for dose escalation.

Development and clinical application of novel polyacrylamide gels in 3Devaluation of inversely planned, intensity modulated radiotherapy dose distributions.



P. Gibbs
L.W. Turnbull
Evaluation of tensor, trace and anisotropic diffusion in differentiation of benign and malignant prostatic tumours.



G. Liney
R. Garcia-Alvarez
L.W. Turnbull
Role of MRI in the delivery of intensity modulated radiotherapy for laryngeal malignancies.

Role of dynamic and functional MRI and proton MR spectroscopy for intracranial tumour localization and intensity modulated radiotherapy delivery



L.W. Turnbull
G. Hall
Determination of diagnostic and staging accuracy of dynamic and conventional MR imaging in suspected ovarian malignancy.

Correlation of current prognostic factors (CA125, FIGO stage) with MR derived and immunohistochemical measurement of parameters of neoangiogenesis.



C. Tan
M. Lowry
D. Manton
Determination of the pharmacokinetics of specific chemotherapeutic agents in liver using 2CSI MR fluorine spectroscopy.