RESEARCH

Directly or indirectly, cancer will touch everyone's lives. There is no greater or more worthwhile challenge than the ongoing battle to develop and improve anti-cancer treatments, for everyone's sake.

programme of research


University of Hull

2003/4

Centre for Magnetic Resonance Investigations Scientific Director: Professor L. W. Turnbull



M. Lowry
D. Manton
P. Gibbs
C. Tan
M. Pickles
L.W. Turnbull
Development of MR spectroscopic techniques for the detection and measurement of choline in / breast tissue. Early prediction of the response of locally advanced primary / breast cancer to neoadjuvant chemotherapy by T1W-dynamic contrast-enhanced MR, 1H spectroscopic imaging and 1/R2 imaging. Development of 32P MR spectroscopy for determination of response of primary / breast tumours to neoadjuvant chemotherapy. Determination of the overall response of locally advanced primary / breast cancer to noadjuvant chemotherapy by DCE-MRI, compared to X-ray mammography, ultrasound and definitive histopathology.


L.W. Turnbull
Use of neural network analysis for prediction of benign / malignant status of / breast lesions using functional and morphological data. M. Sreenivasan P. Gibbs L.W. Turnbull Development, co-ordination, and management of a multi-centre study to determine the comparative effectiveness of MR imaging in women with biopsy proven primary / breast cancer scheduled for wide local excision.



M. Lowry
D. Manton
L.W. Turnbull
Effect of conventional hormone replacement therapy and a specific oestrogen receptor modulator on / breast parenchymal volume and contrast uptake characteristics.


M. Lowry
L.W. Turnbull
Use of spatial grey level dependence for textural analysis determination. P. Gibbs L.W. Turnbull Development of techniques for determination of the extent of intra-prostatic tumour using conventional T2-W FSE imaging, dynamic contrast-enhanced T1W imaging, and 3D MR PROSE spectroscopy.



P. Gibbs
L.W. Turnbull
Evaluation of tensor, trace and anisotropic diffusion in differentiation of benign and malignant prostatic tumours.



L.W. Turnbull
P. Balan
Role of MR imaging in intensity modulated radiotherapy planning of primary prostatic malignancy, with particular reference to tumour localization by ADC and DCE-MRI for dose escalation. Development and clinical application of novel poly-acrylamide gels in 3D evaluation of inversely planned, intensity modulated radiotherapy dose distributions. P. Gibbs G. Liney L.W. Turnbull Role of MRI in the delivery of intensity modulated radiotherapy for laryngeal malignancies. Role of dynamic and functional MRI and proton MR spectroscopy for intracranial tumour localisation and intensity modulated radiotherapy delivery. G. Liney R. Alvarez-Garcia L.W. Turnbull Determination of diagnostic and staging accuracy of dynamic and conventional MR imaging in solid and cystic pelvic mass lesions (gynaecological).



P. Balan
L.W. Turnbull
Role of 3D CSI MR proton spectroscopy in distinguishing benign from malignant gynaecological masses.


P. Balan
L.W. Turnbull
Correlation of current prognostic factors (CA125, FIGO stage) with MR derived and immunohistochemical measurement of parameters of neoangiogenesis.