programme of research

University of Hull

2005/6

Centre for MR Investigations

G.P. Liney
L.W. Turnbull
R. Garcia-AlvarezImpact of Magnetic Resonance (MR) Imaging on the Delivery and Verification of Intensity Modulated Radiotherapy (IMRT) for Cancer Treatment.

Academic Department of Radiology
Yorkshire Cancer Research
Professor of Radiology
Professor L.W. Turnbull

P. Gibbs
G.P. Liney
D. Manton
M. Pickles
M. Sreenivas
M. Lowry
L.W. Turnbull
Differentiation of benign from malignant breast lesions using dynamic contrast-enhanced imaging (DCE-MRI), diffusion-weighted imaging, R2*,T2 mapping, proton MR spectroscopy and textural analysis.

Determination of the role of functional MRI in predicting the outcome of primary tumours early during the course of neoadjuvant chemotherapy.

Use of advanced MRI techniques to determine the residual tumour present post chemotherapy.

Determination of the role of MR imaging in the management of women with primary breast cancer scheduled for wide local excision.

Development of automated techniques for segmentation of breast lesions to evaluate tumour volume.

Development of neural networks for automated breast lesion differentiation.

P. Gibbs
M. Pickles
L.W Turnbull
B. Zelhof
M. Lowry
Quantification of functional MRI at 3T using arterial input function to aid discriminating between benign and malignant tissue.

Assessment of the clinical utility of diffusion-weighted and diffusion tensor imaging at 3T for tissue discrimination.

Development of proton spectroscopy of the prostate at 3T using endo-rectal receiver coil.

Role of various MR biomarkers as prognostic indices.

Role of photodynamic therapy in the treatment of prostate malignancy.

Use of multiple data inputs in optimising radiotherapy delivery for prostate cancer.

G. Liney
R. Garcia-Alvarez
L.W. Turnbull
Use of DCE-MRI in the management of patients with primary head and neck tumours.

Determination of a multi-imaging strategy for including MR imaging and spectroscopy to optimise intensity modulated radiotherapy delivery for brain tumours.

Development of radio-sensitive gels for quantitation and quality assurance of conventional and intensity modulated radiotherapy delivery.

L.W. Turnbull
S. Booth
Optimisation of conventional and dynamic imaging techniques at 3T and development of MR spectroscopic imaging for differentiating between benign and malignant ovarian tumours.

Role of DCE-MRI and other MR techniques in prediction of response of inoperable ovarian tumours to neoadjuvant chemotherapy.

Use of 3T MR imaging in the staging of cancer of the cervix uteri, endometrium and vagina.

Examination of the role of PDT in the treatment of vulval intra-epithelial neoplasia.

School of Pharmacy and Chemistry
Head of Department: Professor J.E. Brown

S. Carrington
J.E. Brown
H. Mackay
Structure-activity studies on novel DNA affinic compounds incorporating oestrogen-receptor ligand, polyamine and antineoplastic moieties.