Directly or indirectly, cancer will touch everyone's lives. There is no greater or more worthwhile challenge than the ongoing battle to develop and improve anti-cancer treatments, for everyone's sake.
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programme of research
University of Hull
2007/08
Academic Department of Radiology
Yorkshire Cancer Research
Professor of Radiology
Professor L W Turnbull
P Gibbs
G Liney
D Manton
M Lowry
P Gibbs
LW Turnbull
Investigation of the role of MR in the management of women at high risk of developing breast cancer
Development of MR techniques for detection and loco-regional staging of DCIS
Early prediction of response to locally advanced breast cancer to chemotherapy using MRI and both proton and phosphorus MR spectroscopy
Establish quality assured foundations for a multi-centre study, including technical achievability of multi-parameter, multi-MR system standardised protocols
Semi-automated tumour segmentation and analysis
Efficacy of different shape parameters for the discrimination of benign and malignant lesions
Algorithm for semi-automatic estimation of tumour volume by 3D segmentation of the DCE-MRI data, using a fuzzy c-means clustering algorithm
P Gibbs
B Zelhof
M Lowry
M Pickles
LW Turnbull
Determine staging accuracy of 3T MR for prostate cancer using various receivers coils
Comparison of MR derived parameters and molecular pathology in tumour staging and prognostication
Comparison of ADC maps and cell density
Quantitative analysis of prostate tumour enhancement curves using an accurate measurement of blood T1 to determine blood contrast concentration for use as an arterial input function (AIF).
Development and evaluation of MR spectroscopic techniques for prostate at 3T
Evaluation of the role of MR in management of PSA positive, biopsy negative patients
Evaluation of MR in exclusion of invasive disease in patients with prostatic intra-epithelial neoplasia (PIN)
M Pickles
LW Turnbull
Comparison of whole body MRI with CT, PET-CT and isotope bone scanning for detection of metastatic tumour spread
Comparison of two point Dixon chemical shift technique for high spatial resolution T1 weighted gradient echo, STIR and VECTOR diffusion weighted imaging for lesion detection
Image fusion by registration of the functional diffusion images onto the morphological T1-weighted images
G Liney
LW Turnbull
Quantitative of bone strength using high resolution MRI pre, during and post chemotherapy in ovarian / breast cancer patients
Measurement of marrow composition from: the fat/water signal ratio using IDEAL; a sophisticated three-point Dixon chemical shift MRI technique and from the fat/water ratio using non water suppressed PRESS; a single-voxel proton spectroscopy technique and development of parameter maps of fat fraction
Comparison of MR results with conventional DEXA scanning and qCT
Development and optimisation of post-processing methodology for qCT for extremities
G Liney
LW Turnbull
Further development of MRI-gel dosimetry to allow radiation distributions to be visualised in exquisite detail for purpose of radiotherapy planning
Explore the design and commercial potential of novel gel-filled phantoms
M Pickles
LW Turnbull
Detection of lymph node spread of malignancy using STIR and VECTOR diffusion weighted imaging in pelvic malignancies in comparison with conventional imaging and radical surgical specimens
S Booth
M Pickles
LW Turnbull
Determine the efficacy of functional in vivo MRI and spectroscopy techniques and ex vivo high resolution magic angle spinning spectroscopy of punch biopsy specimens in predicting response prior to and early during combined chemo-radiotherapy in patients with biopsy proven cervical cancer
Determine the efficacy of pre-treatment molecular pathology from cone biopsies in predicting response to chemo-radiotherapy
Assess ability of in vivo and ex vivo MR and molecular pathology, in predicting disease free and overall survival
Determine optimal techniques necessary to facilitate a multi-centre study
Determine diagnostic and staging accuracy of 3T MRI for ovarian malignancies
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