Directly or indirectly, cancer will touch everyone's lives. There is no greater or more worthwhile challenge than the ongoing battle to develop and improve anti-cancer treatments, for everyone's sake.

programme of research

University of Leeds

2001/2

Research School of Medicine
Director: Professor M.A. Smith

D. Burke
P. Quirke
P.F. Jones
Tumour vascularity, cellular proliferation and the role of angiopoietins in colorectal cancer

P.N. Cockerill
Activation of the GM-CSF locus in acute myeloid leukaemia

P.L. Coletta
C. Bonifer
M.A. Hull
Tumour initiation and progression in the ApcMin mousemodel of familial adenomatous polyposis

J.E. Crabtree
P.A. Robinson
M.F. Dixon
M. Court
The role of Helicobacter pylori cag locus and host inducible nitric oxide synthase on gastric epithelial cell function and mucosal damage

J.E. Crabtree
M. Aboshkiwa
M.F. Dixon
P.A Robinson
Characterisation of host genes associated with the development of helicobactor pylori induced gastric cancer

L.J. Hardie
G.W.B. Clark
C.P. Wild
The role of free radical induced DNA damage during the evolution of oesophageal adenocarcinoma

G. Hawcroft
A.F. Markham
M.A. Hull
Down-regulation ofb-catenin underlies chemoprevention of colorectal cancer by non-steroidal anti-inflammatory drugs

P. Hillmen
B. Kennedy
GPI deficient lymphocyte function and opportunistic infection in patients with chronic lymphocytic leukaemia treated with CAMPATH-1H

M.A. Hull
P.L. Coletta
C. Bonifer
The role of cyclooxygenase-2 (COX-2) in intestinal tumorigenesis

P.F. Jones
A.F. Markham
Identification of new angiopoietins

G.J. Morgan
Investigation and characterisation of genetic abnormalities associated with illegitimate isotope switching rearrangements at 14q32 in multiple myeloma patient material

The role of fibroblast growth factor receptor 3 (FGFR3) in multiple myeloma using an in-vitro model system

E.E. Morrison
J.M. Askham
Interaction between the APC tumour suppressor protein and the mitotic spindle component EB1 and the significance of its disruption in colorectal carcinoma

E.E. Morrison
J.M. Askham
M. Adams
Investigation of the role of TOGp in colorectal cancer

E.E. Morrison
Application of advanced image analysis technology to cancer cell biology

P. Quirke
M. Seymour
Selection of patients for adjuvant therapy in colorectal cancer - getting it right with molecular profiling

I. Martin
D. Hammond
J. Royds
P. Quirke
A collaborative Yorkshire approach to the localisation of genes involved in gastric cancer by sequential comparative genomic hybridisation and microsatellite screening using familial and young onset gastric cancer

V. Speirs
G. Skliris
The significance of estrogen receptor ßin breast cancer

A. Whitehouse
D.J. Goodwin
Kaposi's sarcoma: investigating the Human Herpesvirus-8 latent-lytic switch

A. Whitehouse
K.T. Hall
A.F. Markham
Development of a replication-disabled Herpesvirus saimiri gene transfer vector for the delivery of therapeutic genes to lung carcinoma cells

D.A. Matthews
K.T. Hall
A. Whitehouse
Development of an adenovirus vector which utilises the Herpesvirus saimiri episomal maintenance system to allow efficient long term expression of therapeutic tumour suppressor genes in carcinoma cells

C.P. Wild
D. Forman
M. Scott
Identification of Barrett's oesophagus patients at high risk of progression to oesophageal adenocarcinoma using molecular markers

D.M. Beardsmore
C. Verbeke
C. Davies
P.J. Guillou
G.W.B. Clark
Response to Neoadjuvant Therapy in Oesophageal Cancer: The Role of Survivin, A Novel Inhibitor of Apoptosis

P.J. Guillou
D. Jayne
A.F. Markham
Interactions between mesothelial cells and tumour cells in the generation of peritoneal metastases

P.J. Guillou
D. Jayne
The role of apoptosis in peritoneal invasion

Faculty of Biological Sciences
(School of Biochemistry and Molecular Biology)
Chair of the Faculty: Professor K.T. Holland
Head of the School: Professor A.J. Turner

U. Bugajska
K. Barnes
J. Bentley
E. McIntosh
D. Itchayanan
S.A. Baldwin
Investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation in the pathogenesis of chronic myeloid leukaemia

G.E. Blair
I.G. Martin
P. Quirke
A. Trejdosiewicz
S. Gray
Molecular profiling of gastric and colorectal cancer - analysis of proteins involved in antigen processing

G. Bottley
G.E. Blair
High risk human papilloma virus oncogenes: Studies on antigen processing and presentation in transformed cells, organotypic cultures and tumours

J. Jarvis
G.E. Blair
A study of the potential role of the alanine-rich region of oncogenic adenovirus E1A oncoproteins in tumorigenesis

E. Curti
J.B. Sweasy
J. Jger
A mutator mutant of DNA repair polymeraseß: insights into the structural determinants of nucleotide discrimination and replication fidelity

A.J. Turner
B.A. Usmani
Expression and regulation of the metalloproteinase ECE in prostate cancer

S.C. Wright
Identification of genes that are transcriptionally repressed by mxi1

Yorkshire Cancer Research Photodynamic Therapy Group
Centre for Photobiology and Photodynamic Therapy

(A multidisciplinary group of staff from the School of Biochemistry and Molecular Biology, the School of Biomedical Sciences, the Department of Colour Chemistry, the Research School of Medicine, Cookridge Hospital, Leeds General Infirmary, St James's Hospital and Goole and District Hospital.)

Principal Investigator: Professor S.B. Brown

S.B. Brown
R. Ackroyd
H. van den Akker
A. Bell
D. Berger
A. Brown
M. Brown
N.J. Brown
G.W.B. Clark
R. Cox
M.L. Denti
E. Eagle
A. Foley
J. Griffiths
A.J. Holroyd
J. Howard
C. Kelty
G. Lane
A. Leung
J. Mama
P. Marks
K. Mellish
K. Moghissi
C. O'Grady
M. Parsons
J. Petit
E. Pittard
M.M. Rashid
M W R Reed
D.J.H. Roberts
F. Roberts
J. Schofield
M.R. Stringer
C. Sudworth
E. Taylor
J.A.C. Thorpe
R. Tunstall
R. Tyler
D.I. Vernon
I. Walker
J. Wilson
S.R. Wood
A multidisciplinary approach to the development of photo-dynamic therapy for cancer treatment