programme of research

University of Leeds

2002/3

Research School of Medicine, Dentistry, Psychology and Health
Dean of Research: Professor M A Smith


J.M. Askham
E.E. Morrison
Functional characterisation of human EB1 homologues


S.M. Bell
A.P. Jackson
Characterisation of OSC1, A Novel Tumour Suppressor in Oral Squamous Cell Carcinoma and other Cancers


C. Bonifer
D. Clarke
Expression of oncogenic versions of c-myb and AML1 in in vitro differentiated mouse embryonic stem cells


D. Burke
J. Uddin
P. Jones
P. Quirke
Tumour vascularity, cellular proliferation and the role of angiopoietins in colorectal cancer


P.N. Cockerill
Activation of the GM-CSF locus in acute myeloid leukaemia


P.L. Coletta
C. Bonifer
M.A. Hull
Tumour initiation and progression in the ApcMin mouse model of familial adenomatous polyposis

J.E. Crabtree
M.F. Dixon
P.A. Robinson
Characterisation of host genes associated with the development of Helicobacter pylori induced gastric cancer


D.G. Jayne
D.S. O'Riordain
P.J. Guillou
The role of apoptosis in peritoneal invasion


L.J. Hardie
G.W.B. Clark
C.P. Wild
The role offree radical induced DNA damage during the evolution of oesophageal adenocarcinoma


G. Hawcroft
A.F. Markham
M.A. Hull
Down-regulation of ß-catenin underlies chemoprevention of colorectal cancer by non-steroidal anti-inflammatory drugs


P. Hillmen
B. Kennedy
GPI deficient lymphocyte function and opportunistic infection in patients with chronic lymphocytic leukaemia treated with CAMPATH-1H

G.J. Morgan
D. Gonzalez de Castro
The role of fibroblast growth factor receptor 3 (FGFR3) in multiple myeloma


G.J. Morgan
J. Fenton
Investigation and characterisation of genetic abnormalities associated (14q32) in multiple myeloma


E.E. Morrison
J.M. Askham
Interaction between the APC tumour suppressor protein and the mitotic spindle component EB1 and the significance of its disruption in colorectal carcinoma

E.E. Morrison
J.M. Askham
M. Adams
Investigation of the role of TOGp in colorectal cancer


P. Quirke
M. Seymour
Selection of patients for adjuvant therapy in colorectal cancer. Getting it right with molecular profiling


V. Speirs
G.P. Skliris
The significance of estrogen receptorß in breast cancer


V. Speirs
D.J. Scott
Further defining the role of estrogen receptorßin breast cancer: using variant isoforms to predict hormone response

C.P. Wild
D. Forman
M. Scott
Identification of Barrett's Oesophagus patients at high risk of progression to oesophageal adenocarcinoma using molecular markers

Faculty of Biological Sciences
(School of Biochemistry and Molecular Biology)
Chair of the Faculty: Professor K.T. Holland
Head of the School: Professor A.J. Turner


K. Barnes
E. McIntosh
D. Itchayanan
J. Bentley
S.A. Baldwin
Investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation in the pathogenesis of chronic myeloid leukaemia


G. Bottley
G.E. Blair
High risk human papilloma virus oncogenes: Studies on antigen processing and presentation in transformed cells, organotypic cultures and tumours


B.A. Usmani
A.J. Turner
Functional genomics of a proteinase gene family (M13; NEP) in human prostate cancer


A. Whitehouse
D. Goodwin
Kaposi's sarcoma: investigating the Human Herpesvirus-8 latent-lytic switch


D.A. Matthews
K.T. Hall
A. Whitehouse
Development of an adenovirus vector which utilises the Herpesvirus saimiri episomal maintenance system to allow efficient long term expression of therapeutic tumour suppressor genes in carcinoma cells


S.C.Wright
Identification of genes that are transcriptionally repressed by Mxi1

Yorkshire Cancer Research Photodynamic Therapy Group
Centre for Photobiology and Photodynamic Therapy

(A multidisciplinary group of staff from the School of Biochemistry and Molecular Biology, the School of Biomedical Sciences, the Department of Colour Chemistry, the Research School of Medicine, Cookridge Hospital, Leeds General Infirmary, St James's Hospital and Goole and District Hospital.)

Principal Investigator: Professor S B Brown


S B brown
R Ackroyd
A Bell
D Berger
A br /own
N J br /own
M L Denti
E Eagle
A Foley
S Gorman
J Griffiths
A J Holroyd
C Kelty
G Lane
J Mama
P Marks
K Mellish
K Moghissi
C O'Grady
M Parsons
J Petit
M M Rashid
M W R Reed
D J H Roberts
F Roberts
J Schofield
M R Stringer
C Sudworth
E Taylor
J A C Thorpe
R Tunstall
R Tyler
D I Vernon
I Walker
S R Wood
A multidisciplinary approach to the development of photodynamic therapy for cancer treatment