research publications

University of Leeds

2001/2

Research School of Medicine
Director: Professor M.A. Smith

Crabtree J.E. (2001)
Cytokine responses in Helicobacter pylori infection.
Helicobacter pylori: Molecular and Cellular Biology; Eds M.Achtman and S. Suerbaum, Horizon Scientific Press, Wymondham, UK, 63-83.

Tomita, T., Jackson, A.M., Hida, N., Hayat, M., Dixon, M.F., Shimoyama, T., Axon, A.T.R., Robinson, P.A. and Crabtree, J.E. (2001)
Expression of interleukin-18, a Th1 cytokine, in human gastric mucosa is increased in Helicobacter pylori infection.
Journal of Infectious Diseases 183, 620-627.

Yoshimura, T., Tomita, T., Dixon, M.F., Axon, A.T.R., Robinson, P.A. and Crabtree, J.E. (2002)
ADAMs ( A Disintegrin and Metalloprotease) messenger RNA expression in Helicobacter pylori-infected, normal, and neoplastic gastric mucosa.
Journal of Infectious Diseases 185, 332-340.

Cox, J.M., Clayton, C.L., Tomita, T., Wallace, D.M., Robinson, P.A. and Crabtree, J.E. (2001)
cDNA array analysis of cag pathogenicity island-associated Helicobacter pylori epithelial cell response genes.
Infection and Immunity 69, 6970-6980.

Shimoyama, T., Everett, S.M., Fukuda, S., Axon, A.T.R., Dixon, M.F. and Crabtree, J.E. (2001)
Influence of smoking and alcohol on gastric chemokine mRNA expression in patients with Helicobacter pylori infection.
Journal of Clinical Pathology 54, 332-334.

Crabtree, J.E. (2002)
Role of cytokines in Helicobacter pylori infection.
Helicobacter pylori Infection and Immunity, Eds Y. Yamamoto, H. Friedman, P. Hoffman. Kluwer, Academic Publishers, New York, 203-213.

Zedan, W., Robinson, P.A., Markham, A.F. and High, A.S. (2001)
Expression of the Sonic Hedgehog receptor 'PATCHED' in basal cell carcinomas and odontogenic keratocysts.
Journal of Pathology 194, 473-477.

Ardley, H.C., Tan, N.G.S., Rose, S.A., Markham, A.F. and Robinson, P.A. (2001)
Features of the Parkin/Ariadne ubiquitin ligase, HHARI, which regulates its interaction with the ubiquitin-conjugating enzyme, UbcH7.
Journal of Biological Chemistry 276, 19640-19647.

Hawcroft,, G., D'Amico, M., Albanese, C., Markham, A.F., Pestell, R.G. and Hull, M.A. (2002)
Indomethacin induces differential expression of ?-catenin, ?-catenin and T-cell factor target genes in human colorectal cancer cells.
Carcinogenesis 23, 107-114.

Rawstron, A., Kennedy, B., Evans, P.A.S., Davies, F.E., Richards, S.J., Haynes, A.P., Russell, N.H., Hale, G., Morgan, G.J., Jack, A.S., Hillmen, P. (2001)
Quantitation of minimal disease levels in chronic lymphocytic leukaemia using a sensitive flow cytometric assay improves the prediction of outcome and can be used to optimize therapy.
Blood 98, 29-35

Kennedy, B., Rawstron, A., Carter, C., Ryan, M., Speed, K., Lucas, G. and Hillmen, P. (2002)
Campath-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukaemia.
Blood 99, 2245-2247

Scott, D.J., Hull, M.A., Cartwright, E.J., Lam, W., Tisbury, A., Poulsom, R., Markham, A.F., Bonifer, C. and Coletta, P.L. (2001)
Lack of inducible nitric oxide synthase promotes intestinal tumorigenesis in the ApcMin/+mouse.
Gastroenterology 121, 889-899.

Ward, E.G., Grosios, K., Markham, A.F. and Jones, P.F. (2001)
Genomic structures of the human angiopoietins show polymorphism in Angiopoietin-2.
Cytogenetics and Cell Genetics 94, 147-154.

Jones, P.F. (2001)
The Angiopoietins
The New Angiotherapy pp 41-49. ed. T.P.D. Fan and E.C. Kohn. Humana Press.

Morrison, E. E. and Askham, J. M. (2001)
EB1 immunofluorescence reveals an increase in growing astral microtubule length and number during anaphase in NRK-52E cells.
European Journal of Cell Biology 80(12), 749-753.

Morrison, E. E., Moncur, P. and Askham, J. M. (2002)
EB1 identifies sites of microtubule extension during neurite formation.
Molecular Brain Research 98(1-2), 145-152 (first published online with movie data October 6th 2001).

Birbeck, K.F., Macklin, C.P., Tiffin, N.J., Parsons, W., Dixon, M.F., Mapstone, N.P., Abbott, C.R., Scott, N., Finan, P.J., Johnston, D. and Quirke, P. (2002)
Rates of circumferential resection margin involvement vary between surgeons and predict outcomes in rectal cancer surgery.
Annals of Surgery 235, 449-457.

Jubb, A.M., Bell, S.M. and Quirke, P. (2001)
Methylation and colorectal cancer.
Journal of Pathology 195, 111-134.

Poola, I. and Speirs, V. (2001)
Expression of alternatively spliced estrogen receptor ? mRNAs is increased in malignant breast tissues.
Journal of Steroid Biochemistry and Molecular Biology 78, 459-469.

Achuthan, R., Bell, S.M., Roberts, P., Leek, J.P., Horgan, K., Markham, A.F., MacLennan, K.A. and Speirs, V. (2001)
Genetic events in the transformation of a tamoxifen-sensitive human breast cancer cell line into a drug resistant clone.
Cancer Genetics and Cytogenetics 130, 166-172.

Skliris, G.P., Carder, P.J., Lansdown, M.R.J. and Speirs, V. (2001)
Immunohistochemical detection of ER? in breast cancer: towards more detailed receptor profiling?
British Journal of Cancer 84, 1095-1098.

Skliris, G., Murphy, C.E., Parkes, A.T., Lansdown, M.R.J. and Speirs, V. (2001)
Estrogen receptors and breast cancer: A twenty first-century perspective.
Recent Research Developments in Cancer 3, 163-171.

Goodwin, D.J., Walters, M.S., Smith, P.G., Thurau, M., Fickenscher, H. & Whitehouse, A. (2001)
The Herpesvirus saimiri Rta / ORF 50 protein reactivates the lytic replication cycle in a persistently infected A549 cell line.
Journal of Virology 75, 4008-4013.

Goodwin, D.J. & Whitehouse, A. (2001)
Ag-2 herpesvirus nucleocytoplasmic shuttle protein interacts with importina-1 and importina-5.
Journal of Biological Chemistry 276, 19905-19912.

Smith, P.G., Coletta, P.L., Markham, A.F. & Whitehouse, A. (2001)
In vivo episomal maintenance of a herpesvirus saimiri-based gene delivery vector.
Gene Therapy 8, 1762-1769.

Faculty of Biological Sciences
(School of Biochemistry and Molecular Biology)
Chairman of Faculty: Professor K.T. Holland
Head of the School: Professor A.J. Turner

Bentley, J., Walker, I., McIntosh, E., Whetton, A.D., Owen-Lynch, P.J. and Baldwin, S.A. (2001)
Glucose transport regulation by p210 Bcr-Abl in a chronic myeloid leukaemia model.
British Journal of Haematology 112, 212-215.

Stockwin, L.H., Matzow, T., Georgopoulos, N.T., Stanbridge, L.J., Jones, S.V., Martin, I.G., Blair-Zajdel, M.E. and Blair, G.E. (2002)
Engineered expression of the Coxsackie (B) and adenovirus receptor (CAR) in human dendritic cells enhances recombinant adenovirus-mediated gene transfer.
Journal of Immunological Methods 259, 205-215

Shah, A.M., Conn, D.A., Li, S.X., Capaldi, A., Jger. J., and Sweasy, J.B. (2001)
A DNA polymerase beta mutator mutant with reduced nucleotide discrimination and increased protein stability
Biochemistry 40, 11372-81.

Stoneley, M, Spencer, J.P. and Wright, S.C. (2001)
An internal ribosome entry segment in the 5' untranslated region of the mnt gene
Oncogene 20, 893-897

Fox, E.J. and Wright, S.C. (2001)
S-phase-specific expression of the mad3 gene in proliferating and differentiating cells
Biochem J. 359, 361-367

Yorkshire Cancer Research Photodynamic Therapy Group
Centre for Photobiology and Photodynamic Therapy
Principal Investigator: Professor S.B. Brown

Gederaas, O.A., Holroyd, A., Brown, S. B., Vernon, D., Moan, J. and Berg, K. (2001)
5-Aminolaevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line
Photochem. Photobiol. 73, 164-169

Mayhew, S., Vernon, D. I., Schofield, J., Griffiths, J. and Brown, S. B. (2001)
Investigation of cross-resistance to a range of photosensitizers, hyperthermia and UV light in two radiation-induced fibrosarcoma cell strains resistant to photodynamic therapy in vitro
Photochem. Photobiol. 73, 39-46

Ball, D. J., Mayhew, S., Vernon, D. I., Griffin, M. and Brown, S. B. (2001)
Decreased efficiency of trypsinization of cells following photodynamic therapy: evaluation of a role for tissue transglutaminase
Photochem. Photobiol. 73, 47-53

Mellish, K. J. and Brown, S. B. (2001)
Verteporfin: a milestone in opthalmology and photodynamic therapy
Expert Opinion Pharmacother. 2, 351-361