research publications

University of Leeds

2005/6

FACULTY OF MEDICINE AND HEALTH
Dean of the Faculty: Professor E.W. Hillhouse

The Leeds Institute of Molecular Medicine
Director: Professor T.H. Rabbits

Academic Unit of Oncology & Haematology
Head of Academic Unit: Professor P.J. Selby

de Tute, R., Yuille, M., Catovsky, D., Houlston, R.S., Hillmen, P. and Rawstron, A.C. (2006)
Monoclonal B-cell lymphocytosis (MBL) in CLL families: substantial increase in relative risk for young adults
Leukemia 20, 728-9

FACULTY OF MEDICINE AND HEALTH
Dean of the Faculty: Professor E.W. Hillhouse

The Leeds Institute of Genetics, Health and Therapeutics (LIGHT)
Acting Director: Professor C.P. Wild

Centre for Epidemiology and Biostatistics
Head of Centre : Professor C.P. Wild

Crallan, R.A., Ingham, E. and Routledge, M.N. (2005)
Wavelength dependent responses of primary human keratinocytes to combined treatment with benzo[a]pyrene and UV light
Mutagenesis 20, 305-310

Olliver, J.R., Hardie, L.J., Gong, Y.Y., Dexter, S., Chalmers, D., Harris, K.M. and Wild, C.P. (2005)
Risk factors, DNA damage and disease progression in Barrett's esophagus
Cancer Epidemiology, Biomarkers and Prevention 14(3), 620-625

The Leeds Institute of Molecular Medicine
Director: Professor T.H. Rabbitts

Academic Unit of Molecular Medicine
Director: Professor D.T. Bonthron

Bransfield, K.L., Askham, J.M., Leek, J.P., Robinson, P.A. and Mighell, A.J. (2006)
Phenotypic changes associated with DYNACTIN-2 (DCTN2) over expression characterise SJSA-1 osteosarcoma cells
Mol Carcinog. 45, 157-63

Riess, N.P., Milward, K., Lee, T., Adams, M., Askham, J.M. and Morrison, E.E. (2005)
Trapping of normal EB1 ligands in aggresomes formed by an EB1 deletion mutant
BMC Cell Biology 6, 17

Coggins, R., Cawkwell, L., Bell, S.M., Crockford, G.P., Quirke, P., Finan, P. and Bishop, D.T. (2005)
Association between family history and mismatch repair in colorectal cancer
Gut 54(5), 636-642

Jassam, N., Bell, S.M., Speirs, V. and Quirke, P. (2005)
Loss of expression of oestrogen receptorb in colon cancer and its association with Dukes' staging
Oncology Reports 14,17-21

Tagoh, H., Schebesta, A., Wilson, N., Hume, D.A., Busslinger, M., and Bonifer, C. (2004)
Epigenetic silencing of the c-fms locus during B-lymphopoiesis occurs in discrete steps and is reversible
EMBO J. 23, 4275-4285

Tagoh, H., Ingram, R., Wilson, N., Salvagiotto, G.,Warren, A.J., Clarke, D., Busslinger, M., and Bonifer, C. (2006)
The mechanism of repression of the myeloid-specific c-fms gene by Pax5 during B lineage restriction
EMBO J. 22, 1070-1080

Hull, M.A., Faluyi, O.O., Ko, C.W.S., Holwell, S., Scott, D.J., Cuthbert, R.J., Poulsom, R., Goodlad, R., Bonifer, C., Markham, A.F., Coletta, P.L. (2006)
Regulation of stromal cell cyclooxygenase-2 expression in the ApcMin/+ mouse model of intestinal tumorigenesis
Carcinogenesis 27, 382-391

Naumann, M. and Crabtree, J.E. (2005)
Helicobacter pylori-mechanisms for inducing epithelial cell proliferation
Cambridge University Press, UK, 169-198

Peek, R.M. and Crabtree, J.E. (2006)
Helicobacter infection and gastric neoplasia
Journal of Pathology 208, 233-248

Crabtree, J.E. and Naumann, M. (2006)
Epithelial signalling in Helicobacter pylori infection
Current Signal Transduction Therapy 1, 53-65

Jeremy, A.H.T., Du, Y., Dixon, M.F., Robinson, P.A. and Crabtree, J.E. (2006)
Protection against Helicobacter pylori infection in the Mongolian gerbil after prophylactic vaccination
Microbes and Infection 8, 340-346

Du, Y., Agnew, A., Ye, X., Robinson, P.A., Forman, D. and Crabtree, J.E. (2006)
Helicobacter pylori and Schistosoma japonicum co-infection in a Chinese population: helminth infection alters humoral responses to H. pylori and serum pepsinogen I/II ratio
Microbes and Infection 8, 52-60

Carder, P.J., Murphy, C.E., Dervan, P., Kennedy, M., McCann, A., Saunders, P.T.K., Shaaban, A.M., Foster, C.S., Witton, C.J., Bartlett, J.M.S., Walker, R.A. and Speirs, V. (2005)
A multi-centre investigation towards reaching a consensus on the immuno-histochemical detection of ERb in archival formalin-fixed paraffin embedded human breast tissue
Breast Cancer Research and Treatment 92, 287-293

Waterworth, A., Hanby, A.M. and Speirs, V. (2005)
A novel cell array technique for high throughput cell based analysis
In Vitro Cellular and Developmental Biology 41, 185-187

Jassam, N., Bell, S.M., Speirs, V. and Quirke, P. (2005)
Loss of expression of oestrogen receptorb in colon cancer and its association with Dukes' staging
Oncology Reports 14, 17-21

Pollitt, M.J.K., Hanby, A.M., Horgan, K., Murphy, C.E., Jones, P.F. and Speirs, V. (2005).
Angiogenesis in breast cancer: how should we measure this?
Oncology Reports 13, 931-936 (2005)

Academic Unit of Oncology & Haematology
Head of Academic Unit: Professor P.J. Selby

Sak S.C., Barrett J., Paul A.B., Bishop D.T., Kiltie A.E. (2005)
The polyAT, intronic IVS13-6 and Lys939Gln XPC polymorphisms are not associated with transitional cell carcinoma of the bladder
Br J Cancer 92, 2262-2265

Sak S.C., Harnden P., Johnston C., Paul A.B., Kiltie A.E. (2005)
APE1 and XRCC1 protein expression levels predict cancer specific survival following radical radiotherapy in bladder cancer
Clinical Cancer Research 11, 6205-6211

FACULTY OF BIOLOGICAL SCIENCES
Dean of the Faculty: Professor A.J. Turner

Bottley, G., Cook, G.P., Meade, J.L., Holt, J.R., Hoeben, R.C. and Blair, G.E. (2005)
Differential expression of LFA-3, Fas and MHC Class I on Ad5- and Ad12-transformed human cells and their susceptibility to lymphokine-activated killer (LAK) cells
Virology 338, 297-308

Walters, M.S., Hall, K.T. and Whitehouse, A. (2005)
The herpesvirus saimiri Rta protein autostimulates via binding to a non-consensus response element
Journal of General Virology 86, 581-587

Williams, B., Boyne, J.R., Goodwin, D.J., Roaden, L.R., Wilson, S.A. and Whitehouse, A. (2005)
The prototype gamma-2 herpesvirus nucleocytoplasmic shuttle protein, ORF 57, transports viral RNA via the cellular mRNA export pathway
Biochemical Journal 387, 295-308

Smith, P.G., Oakley, F., Fernandez, M., Mann, D., Lemoine, N.R. and Whitehouse, A. (2005)
Herpesvirus saimiri-based vector biodistribution using non-invasive optical imaging
Gene Therapy 12, 1465-1476

Calderwood, M.A., White, R.E., Griffiths, R.A. and Whitehouse, A. (2005)
Open reading frame 73 is required for Herpesvirus saimiri All-S4 episomal persistence
Journal of General Virology 86, 2703-2708

Wakenshaw, L., Walters, M.S. and Whitehouse, A. (2005)
Herpesvirus saimiri Rta and cEBPa act synergistically to activate the DNA polymerase promoter
Journal of Virology 79, 13548-13560

Awano, S., Dawson, L.A., Hunter, A.R., Turner, A.J., Usmani, B.A. (2006)
The endothelin system in oral squamous carcinoma cells: Specific siRNA targeting of ECE-1 blocks cell proliferation
Int. J. Cancer 118(7), 1645-1652

Professor P. Quirke

Marr R, Birbeck K, Garvican J, Macklin CP, Tiffin NJ, Parsons WJ, Dixon MF, Mapstone NP, Sebag-Montefiore D, Scott N, Johnston D, Sagar P, Finan P & Quirke P. (2005)
The modern abdominoperineal excision: the next challenge after total mesorectal excision
Ann Surg, 242 (1):74-82

Nagtegaal ID, van de Velde CJH, Marijnen, van Krieken JHJM & Quirke P (2005)
Low rectal cancer; a call for a change of approach in abdominoperineal resection. For the pathology review committee and the cooperative clinical investigators of the Dutch ColoRectal Cancer Group
J Clin Oncol, 23, (36):9257-64

Quirke P. (2005)
Optimal management of rectal cancer V the role of the pathologist in optimal management of rectal cancer Glimelius B
Eur J Cancer ECCO 13, supplement pp349-357

Sharma-Oates A, Quirke P, Westhead DR. & TmaDB (2005).
A repository for tissue microarray data
BMC Bioinformatics, 1;6:218