research publications

UNIVERSITY OF LEEDS   

2007/08
 
Faculty of Medicine and Health
Dean of the Faculty: Professor E.W. Hillhouse  

The Leeds Institute of Genetics, Health and Therapeutics (LIGHT)
Director: Professor C.P. Wild  


Reinbold, M., Luo, J-L., Nedelko, T., Jerchow, B., Murphy, M.E., Whibley, C., Wei, Q., and Hollstein, M. (2007)
Common tumour p53 mutations in immortalized cells from Hupki mice heterozygous at codon 72 Oncogene. Nov 12 [Epub ahead of print]    


The Leeds Institute of Molecular Medicine
Director: Professor T. Rabbitts  


Bert, A.G., Johnson, B.V., Baxter, E.W. and Cockerill, P.N. (2007)
A modular enhancer is differentially regulated by GATA and NFAT elements that direct different tissue-specific patterns of nucleosome positioning and inducible chromatin remodeling
Molecular Celular Biology 27, 2870-2885.  

Scott, G.B., Meade, J.L. and Cook, G.P. (2007).
Profiling killers; unravelling the pathways of human natural killer cell function. 
Briefings in Functional Genomics and Proteomics. Advance on-line publication
DOI:10,1093.  

El-Sherbiny, Y.M., Meade, J.L., Holmes, T.D., McGonagle, D., Mackie, S.L., Morgan, A.W., Cook, G., Feyler, S., Richards, S.J., Davies, F.E., Morgan, G.J. and Cook, G.P. (2007)
The requirement for DNAM-1, NKG2D and NKp46 in the NK cell-mediated killing of myeloma cells.
Cancer Research 67, 8444-8449.  

Du, Y., Danjo, K., Robinson, P.A. and Crabtree, J.E. (2007)
In-Cell Western analysis of Helicobacter pylori-induced phosphorylation of extracellular-signal related kinase via the transactivation of the epidermal growth factor receptor.
Microbes and Infection 9, 838-846.  

Wilson, K.T. and Crabtree, J.E. (2007)
Immunology of Helicobacter pylori: insights into the failure of the immune response and perspectives on vaccine studies.
Gastroenterology 133, 288-308.  

Robins, G., Crabtree, J.E., Bailey, A. and Forman, D. (2008)
International variation in Helicobacter pylori infection and rates of oesophageal cancer.
European Journal of Cancer 44, 726-732.  

Dzierzanowska-Fangrat, K., Michalkiewicz, J., Cielecka-Kuszyk, J., Nowak, M., Celinska-Cedro, D., Rozynek, E., Dzierzanowska, D. and Crabtree, J.E. (2008)
Enhanced gastric IL-18 mRNA expression in Helicobacter pylori infected children is associated with macrophage infiltration, IL-8, and IL-1ß mRNA expression.
European Journal of Gastroenterology and Hepatology 20, 314-319.  

Hull, M.A. (2008)
Molecular pathways leading to cancer as a basis for preventive strategies.
Current Colorectal Reports 4, 47-51  

Morrison, E.E. (2007)
Action and interactions at microtubule ends.
Cellular and Molecular Life Sciences 64, 307-317.  

Lee, T., Langford, K.J., Askham, J.M., Bruning-Richardson, A. and Morrison, E.E. (2007)
MCAK associates with EB1.
Oncogene, advance online publication Oct 29th 2007.  

Valleley, E.M.A., Cordery, S.F. and Bonthron, D.T. (2007)
Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters.
Human Molecular Genetics 16, 972-981.  

Carr, I.M., Valleley, E.M.A., Cordery, S.F., Markham, A.F. and Bonthron D.T. (2007)
Sequence analysis and editing for bisulphite genomic sequencing projects.
Nucleic Acids Research 35, e79.  

Maughan, N.J., Morris, E., Forman, D. and Quirke, P. (2007)
The validity of the Royal College of Pathologists' colorectal cancer minimum dataset within a population.
British Journal of Cancer 97, 1393-1398.  Epub 2007 Oct 16.  

Morris, E.J.A., Maughan, N.J., Forman, D. and Quirke, P. (2007)
Identifying stage III colorectal cancer patients: the influence of the patient, surgeon, and pathologist.
Journal of Clinical Oncology 25, 2573-2579.  

Morris, E., Maughan, N.J., Forman, D. and Quirke, P. (2007
Who to treat with adjuvant therapy in Dukes B/stage II colorectal cancer? - The need for high quality pathology.
Gut 56, 1419-1425.  Epub 2007 May 9.  

Quirke, P., Williams, G.T., Ectors, N., Ensari, A., Piard, F. and Nagtegaal, I. (2007)
The future of the TNM staging system in colorectal cancer: time for a debate?
Lancet Oncology 8, 651-657.  

Quirke, P. and Morris, E. (2007)
Reporting colorectal cancer.
Histopathology 50, 103-112.  

Nagtegaal, I.D. and Quirke, P. (2007)
Colorectal tumour deposits in the mesorectum and pericolon; a critical review.
Histopathology 51, 141-149.  Epub 2007 May 26.    


Faculty of Biological Sciences
Dean of the Faculty: Professor S.W. Homans  

Institute of Molecular and Cellular Biology
Director: Professor N.M. Hooper  


Bottley, G., Cook, G.P. and Blair, G.E. (2007)
A flow cytometric assay for analysis of natural-killer cell-mediated cytolysis of adenovirus-transformed cells.
Methods in Molecular Medicine 131, 221-230.  

Bottley, G., Watherston, O.G., Hiew, Y-L., Norrild, B., Cook, G.P. and Blair, G.E. (2007)
High risk Human Papillomavirus (HPV) E7 expression reduces cell-surface MHC class I molecules and increases susceptibility to Natural Killer (NK) cells.
Oncogene, advance on-line publication DOI 1210798.  

Perry, S.E., Robinson, P., Melcher, A., Quirke, P., Bühring, H-J., Cook, G.P. and Blair, G.E. (2007)
Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells.
FEBS Letters 581, 1137-1142.   

Dawson, L.A. and Usmani, B.A. (2008)
Design, manufacture and assay of the efficacy of siRNA's for gene silencing.
Methods in Molecular Biology 439, 397-413  

Wilson, S.J., Tsao, E.H., Webb, B.L.J., Ye, H., Dalton-Griffin, L., Tsantoulas, C., Gale, C.V., Du, M-Q., Whitehouse, A. and Kellam, P. (2007).
XBP-1 transactivates the KSHV ORF50 promoter, linking plasma cell differentiation to KSHV reactivation from latency.
Journal of Virology 81, 13578-13586.  

Boyne, J.R., Colgan, K.J. and Whitehouse, A. (2008)
Herpesvirus saimiri ORF57: a post-transcriptional regulatory protein.
Frontiers in Bioscience 13, 2928-2938.  

Stead, M.A., Trinh, C.H., Garnett, J.A., Carr, S.B., Baron, A.J., Edwards, T.A. and Wright, S.C. (2007)
A Beta Sheet interaction interface directs tetramerisation of the Miz-1 POZ domain. 
Journal of Molecular Biology 373, 820-826