RESEARCH

Directly or indirectly, cancer will touch everyone's lives. There is no greater or more worthwhile challenge than the ongoing battle to develop and improve anti-cancer treatments, for everyone's sake.

programme of research


University of Sheffield

2002/3


YCR Director of Cancer Research - Professor B W Hancock
Central Research Facilities

Clinical Trials Centre
R.E. Coleman
B.W. Hancock
Clinical trials service


Division of Genomic Medicine
Section of Oncology & Pathology
(YCR Institute for Cancer Studies, YCR Academic Unit of Clinical Oncology, Academic Unit of Pathology)
YCR Institute for Cancer Studies

M. Meuth
A. Mohindra
J. Lee
S. Cross
Mechanisms of genetic instability in tumour cells

J.A. Royds
T.H. Jones
A cytokine involvement in thepathogenesis and tumour progressionof pituitary adenomas

T. Helleday
Molecular mechanism for geneticinstability caused by inactivation of poly(ADP-ribose) polymerase


YCR Academic Unit of Clinical Oncology

R.E. Coleman
B.W. Hancock
M.H. Robinson
M. Marples
P.C. Lorigan
Clinical research programme


Academic Unit of Pathology

C.E. Lewis
N.J. Brown(Division of Clinical Sciencesdelivering(S))
F. Hamdy (Division of Clinical Sciences (S))
N. Maitland (YCR Cancer Research Unit, University of York)
Development of Trojan horse system for gene therapy to human tumours


Section of Functional Genomics
Academic Unit of Respiratory Medicine

C.D. Bingle
M.K. Whyte
Regulation of splicing of the cellular survival gene Mc1-1

C.D. Bingle
HE4, a novel cancer marker? Expression and function


Division of Clinical Sciences (N)
Academic Department of Human Metabolism

J.D. Newell-Price
K.A. Al- Sakkaf (Divisionof Genomic Medicine)
M. Reed (Division of Clinical Sciences (S))
B.L. Brown & P.R.M. Dobson (Division of Genomic Medicine)
R.J.M. Ross
Obesity and breast cancer

S. MacNeil
J.W. Haycock(Department of EngineeringMaterials)
P. Lorigan (Divisionof Genomic Medicine)
Examination of early melanoma metastasis in reconstructed human skin


Division of Clinical Sciences (S)
Section of Surgical & Anaesthetic Sciences
Academic Unit of Ophthalmology& Orthoptics

K. Sisley
I.G. Rennie
An in vitro study of posterior uveal melanomainvasions and the potential regulatoryinfluence of HGR and TCF-b


Academic Urology Unit

F.C. Hamdy
Development of novel model systems tostudy cellular interactions between prostatecancer and bone marrow stroma


Department of Biomedical Science

P.W. Andrews
Different action of malignant stem cells:mechanisms of restriction

P.W. Ingham
Maintenance of Leica imaging system


Department of Human Metabolism

S. MacNeil
J.W. Haycock
P. Lorigan
Melanocortins and Melanoma Invasion


Department of Molecular Biology & Biotechnology

A. S. Goldman
Determining how the MRE11 complexregulate 5' to 3' resection duringrecombination