programme of research

University of Sheffield

2004/5

YCR Director of Cancer Research Professor B W Hancock

DIVISION OF GENOMIC MEDICINE:

SECTION OF ONCOLOGY & PATHOLOGY
(YCR Institute for Cancer Studies, Academic Unit of Clinical Oncology, Academic Unit of Pathology)

YCR Institute for Cancer Studies

M. Meuth
Genetic instabilities and cancer.

M. Meuth
P.W. Ingham FRS (Centrefor Developmental Genetics,Department of Biomedical Science)
Azebrafish model for HNPCC; isolation of MMR deficient zebrafish.

T. Helleday
Molecular mechanism for geneticinstability caused by inactivation of poly(ADP-ribose) polymerase.

C. M. Sanders
A. Anston(University of York)
A structural investigation of thepapillomavirus replication initiation complexes.


Academic Unit of Clinical Oncology

R.E. Coleman
B.W. Hancock
M. Marples
M.H. Robinson
P.J. Woll
Y.M. Zhu
In collaboration with:
S. Ahmedzai (Division of Clinical Sciences (S))
F.C. Hamdy (Division of Clinical Sciences (S))
Professor M.W.R. Reed (Academic Unit of Surgical Oncology,
Division of Clinical Sciences (S))
I.G. Rennie (Division of Clinical Sciences (S))
Clinical Research


Academic Unit of Pathology

C.E. Lewis
N. Maitland (YCRCancer Research Unit, University
of York)
F. Hamdy (Academic Unit of Urology, Division of Clinical
Sciences (S))
N.J. Brown (Micro-circulation Research Group, Academic
Unit of Surgical Oncology, Division of Clinical Sciences (S))
Development of Trojan horse system for delivering gene therapy to human tumours.

C.E. Lewis
P.W. Ingham FRS(Centre for DevelopmentalGenetics, Department ofBiomedical Science)
Establishment of zebrafish model of angiogenesis.

C.E. Lewis
J. Green
Novel use of hypoxia response promoters in salmonella to target genes to hypoxicareas of breast tumours.


SECTION OF FUNCTIONAL GENOMICS

Academic Unit of Infection & Immunity

A. Heath
Novel, highly immunogenic ganglioside-based cancer vaccines.


Academic Unit of Respiratory Medicine

C.D. Bingle
HE4, a novel cancer marker? Expression andfunction.


DIVISION OF CLINICAL SCIENCES (S)
Academic Unit of Urology

A.A.G. Bryden
A.M. Scutt
C.L. Eaton
B. Thomas
F.C. Hamdy
Development of novel model systems to study cellular interactions between prostatecancer and bone marrow stroma.

C. Eaton
F.C. Hamdy
I. Holden(Academic Unit of Clinical Oncology,Division of Genomic Medicine)
The role of osteoprotegerin (OPG) on prostate cancer survival.


DEPARTMENT OF BIOMEDICAL SCIENCE

P.W. Andrews
A screen of candidate regulatory genes thatmay play a role in the progression oftesticular germ cell tumours.

P.W. Andrews
Regulation of pluripotency in malignant stem cells.

P.W. Ingham FRS (Centre forDevelopmental & Biomedical Genetics)
Maintenance of Confocal Imaging System.

DEPARTMENT OF MOLECULAR BIOLOGY & BIOTECHNOLOGY

L.J. Partridge
Characterisation of human antibodies toovarian tumour marker.

A.S. Goldman
Determining how the MRE11 complexregulate 5 to 3 resection during recombination.

P.W. Piper (Krebs Institute)
Seeking the conserved function of the MAGEhomology domain present in melanomaantigen.


SCHOOL OF CLINICAL DENTISTRY
Department of Oral Pathology

S.A. Whawell
P.M. Speight
D.A. Devine (Leeds Dental Institute,University of Leeds)
The role of host defence peptides in epithelial tumour biology.


Academic Unit of Ophthalmology and Orthoptics
Head of Department: Professor I G Rennie

I.G. Rennie
K. Sisley
An in vitro study of posterior uveal melanoma invasion and the potential regulatory influences of HGF and TGF-b