programme of research

University of Sheffield

2006/7

Faculty of Medicine
School of Medicine and Biomedical Sciences

Section of Oncology
YCR Institute for Cancer Studies

A. Cox
The effect of single nucleotide polymorphisms on clinical outcome and survival in the FOCUS clinical trial of metastatic colorectal cancer.

T. Helleday
The role of Poly(ADP-ribosyl) polymerase in replication.

T. Helleday
The role for replication protein A in maintaining gentic stability.

M. Meuth
Genetic instability and cancer.

C.M. Sanders
A structural investigation of the papillomavirus replication initiation complexes.

C.M. Sanders
T. Helleda
M. Meuth
Cell-cycle regulation of DNA replication in mammalian cells (equipment grant).


Academic Unit of Urology

C.L. Eaton
The role of osteoprotegerin on prostate cancer survival.

Academic Unit of Surgical Oncology

N.J. Brown
Influence of tumour cell death mechanisms and immunoregulatory T cells on tumour growth and immunity.

C.A. Staton
The relationship between tissue factor and vascular endothelial growth factor in breast cancer.


Academic Unit of Ophthalmology and Orthoptics

K. Sisley
I. Rennie
Do the aqueous and vitreous humors of the eye determine the invasive behaviour of uveal melanomas?


Section of Infection, Inflammation and Immunity
Academic Unit of Pathology

C. Lewis
Development of a macrophage-based system to target therapeutic viruses to prostate cancer. 

C. Lewis
Use of Novel, Hypoxia-inducible bacterial promotes in salmonella to target hypoxic areas of breast tumours.

C. Lewis
Macrophage responses to hypoxia: relative contribution to tumour angiogenesis and progression.


Academic Unit of Infectious Diseases

A. Heath
Novel, highly immunogenic ganglioside based cancer vaccines.

A. Heath and J. Carling
Improved idiotype vaccines for cancer.


Department of Biomedical Sciences

P.W. Andrews
Regulation of pluripotency in malignant stem cells.