programme of research

University of Sheffield

2007/08


Faculty of Medicine
School of Medicine and Biomedical Sciences  
 
Section of Oncology  
YCR Institute for Cancer Studies  

  
A. Cox                        
P. Quirke                     
M. Seymour
The effect of single nucleotide polymorphisms on clinical outcome and survival in the FOCUS clinical trial of metastatic colorectal cancer.

A. Cox                        
F. Hamdy
M.W.R. Reed
J. Donovan
D. Neal  
Variation in apoptosis genes and susceptibility to common cancers 

A. Cox                       
Liquid handling robot for cancer genetic epidemiology  

T. Helleday    
H. Bryant                
The role of Poly(ADP-ribosyl) polymerase in replication.    
  
T. Helleday                  
K. Sleeth     
The role for replication protein A in maintaining gentic stability  

M. Meuth                     
Genetic instability and cancer.    

C.M. Sanders      
A. Antson        
A structural investigation of the papillomavirus replication initiation complexes.


Academic Unit of Surgical Oncology    

N.J. Brown                 
A.G. Pockley             
M.W.R. Reed
S.L. Hankin
Influence of tumour cell death mechanisms and immunoregulatory T cells on tumour growth and immunity.    

C.A. Staton                
M.W.R. Reed             
N.J. Brown     
The relationship between tissue factor and vascular endothelial growth factor in breast cancer.


Academic Unit of Ophthalmology and Orthoptics    

K. Sisley                    
I. Rennie                    
Identifying novel regulators of uveal melanoma invasion within the awueous and vitrious homors.


Section of Infection, Inflammation and Immunity    
Academic Unit of Pathology   
 
C. Lewis                    
J. Green
J. Harmey
R. Ryan  
Novel use of hypoxia response promoters in Salmonella to target genes to hypoxic   

C. Lewis                    
C. Murdoch                
R. Johnson
Macrophage responses to hypoxia: relative contribution to tumour angiogenesis and progression. 

J. Bury                    
N. Green
S. MacNeil
B. Corfe
G. Battaglia 
 Integrative modelling of the molecular pathogenesis of Barrett's metaplasia  


Academic Unit of Infectious Diseases    

A. Heath                      
J.  Carlring Wright 
Tumour vaccines with enhanced Immunogenicity  


Department of Biomedical Sciences    

P. Rashbass             
S.S. Cross
J. Catto 
The role of Crumbs2 in epithelial to mesenchymal transition and tumour progression. 

P.W. Andrews            
Regulation of pluripotency in malignant stem cells.  

P.W. Andrews           
M. Meuth  
Genetic changes in cultured hES cells as a model for germ cell tumour development.


School of Clinical Dentistry    

S. Whawell                
P.M. Speight
A.J. Turner 
Regulation of malignant epithelial cell behaviour by integrin-ADAM interactions.