research publications

University of Sheffield

2004/5

Azmy, I.A.F., Balasubramanian, S.P., Wilson, A.G., Stephenson, T.J., Cox, A., Brown, N.J., and Reed, M.W.R. (2004)
Role of tumour necrosis factor gene polymorphisms (-308 and -238) in breast cancer susceptibility and severity.
Breast Cancer Research 6, R395-R400.

Bates, M., Everard, J., Wall, L., Horsman, J.M. and Hancock, B.W. (2004)
Is there a relationship between treatment for infertility and gestational trophoblastic disease?
Human Reproduction 19, 365-367.

Bolderson, E., Scorah, J., Helleday, T., Smthye, C and Meuth, M. (2004)
ATM is required for the cellular response to thymidine induced replication fork stress.
Human Molecular Genetics 13(23), 2937-2945.

Bryant, H.E. and Helleday, T. (2004)
Poly(ADP-ribose) polymerase inhibitors as potential chemotherapeutic agents.
Biochemical Society Transactions 32, 959-961.

Coleman, R.E. (2004)
The role of bisphosphonates in breast cancer.
The Breast 13 S19-S28.

Coleman, R., Heidenreich, A. and Bell, R. (2004)
Managing metastatic bone disease: Three case studies.
Seminars in Oncology 31, 83-86.

Cunliffe, V.T. (2004)
Histone deacetylase 1 is required to repress Notch target gene expression during zebrafish neurogenesis and to maintain the production of motoneurones in response to hedgehog signalling.
Development 131, 2983-2995.

El-Helw, L., Goodwin, S., Slater, D and Hancock, B.W. (2004)
Primary B-cell lymphoma of the skin: The Sheffield Lymphoma Group Experience (1984-2003).
International Journal of Clinical Oncology 25, 1453-1458.

Hall, G.D., Brown, J.M., Coleman, R.E., Stead, M., Metcalf, K.S., Peel, K.R., Poole, C., Crawford, M., Hancock, B., Selby, P.J. and Perren, T.J. (2004)
Maintenance treatment with Interferon for Advanced Ovarian Cancer: results of the Northern and Yorkshire Gynaecology Group randomised Phase III study.
British Journal of Cancer 91, 621-626.

Hancock, B.W., Wheatley, K., Harris, S., Ives, N., Harrison, G., Horsman, J.M., Middleton, MR, Thatcher, N., Lorigan, P.C., Marsden, J.R., Burrows, L. and Gore, M. (2004)
Adjuvant Interferon in High-Risk Melanoma: The AIM HIGH Study United Kingdom Coordinating Committee on Cancer Research randomized study of adjuvant low-dose extended-duration Interferon Alfa-2a in high-risk resected malignant melanoma.
Journal of Clinical Oncology 22, 53-61.

Hancock, B.W. (2004)
Gestational Trophoblastic Disease.
In: Obstetrics and Gynaecology. An evidence-based text for MRCOG.
Eds. David M. Luesley and Philip N. Baker.
Publ. Arnold, Hodder Headline Group, London. 756-761.

Hart, S., Horsman, J.M., Radstone, C.R., Hancock, H., Goepel, J.R. and Hancock, B.W. (2004)
Localised extranodal lymphoma of the head and neck: the Sheffield Lymphoma Group Experience (1971 2000).
Clinical Oncology 16, 186-192.

Kumari, A., Schultz, N. and Helleday, T. (2004)
p53 protects from replication-associated DNA double-strand breaks in mammalian cells.
Oncogene, 23, 2320-2325.

MacPherson, G., Healey, C.S., Teare, D., Balasubramanian, S.P., Reed, M.W., Pharoah, P.D.P., Ponder, B.A.J., Meuth, M., Bhattacharyya, N.P., and Cox, A. (2004)
Common variants of genes involved in apoptosis are associated with breast cancer.
Journal of the National Cancer Institute 96, 1866-1869.

Matin M.M, Walsh, J.R, Gokhale, P.J, Draper, J.S, Bahrami, A, Morton, I, Moore, H.D. and Andrews, P.W. (2004)
RNA interference mediated knock-down of Oct4 expression induces differentiation of human EC and ES cells.
Stem Cells 22, 659 668.

Mohindra, A., Bolderson, E., Stone, J., Wells, M., Helleday, T. and Meuth, M. (2004)
A tumour-derived mutant allele of XRCC2 preferentially suppresses homologous recombination at DNA replication forks.
Human Molecular Genetics 13, 203-212.

Nakano, Y., Nystedt, S., Shivdasani, A.A., Strutt, H., Thomas, C. and Ingham, P.W. (2004)
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila.
Mechanisms of Development 121, 507-518.

Nakano, Y., Kim, H.R., Kawakami, A., Roy, S., Schier, A.F. and Ingham, P.W. (2004)
Inactivation of dispatched 1 by the chameleon mutation disrupts Hedgehog signalling in the zebrafish embryo.
Developmental Biology 15, 269, 381-392.

Neville-Webbe, H.L., Cross, N.A., Eaton, C.L., Nyambo, R., Evans, C.A., Coleman, R.E. and Holen, I. (2004)
Osteoprotegerin (OPG) produced by bone marrow stromal cells protects breast cancer cells from TRAIL-induced apoptosis.
Breast Cancer Research and Treatment 86, 269-279.

Nyambo, R, Cross, N, Lippitt, J, Holen, I, Bryden, G., Hamdy, F.C and Eaton, C.L. (2004)
Human bone marrow stromal cells protect prostate cancer cells from TRAIL induced apoptosis.
Journal of Bone & Mineral Research 19, 1712-1721.

Pisal, N., Tidy, J. and Hancock, B. (2004)
Gestational trophoblastic disease: is intensive follow up essential in all women?
British Journal of Obstetrics & Gynaecology 111, 1449-1451.

Saleh-Gohari, N. and Helleday, T. (2004)
Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells.
Nucleic Acids Research, 32, 3683-3688.

Saleh-Gohari, N. and Helleday, T. (2004)
Strand invasion involving short tract gene conversion is specifically suppressed in BRCA2-deficient hamster cells.
Oncogene 23, 9136-9141.

Strutt, H., Mundy, J., Hofstra, K. and Strutt, D. (2004)
Cleavage and secretion is not required for Four-jointed function in Drosophila patterning.
Development 131,881-890.

Teare, M.D., Cox, A., Shorto, J., Anderson, C., Bishop, D.T. and Cannings, C. (2004)
Genotype specific selection is repeatedly observed in females at the BRCA2 locus N372H.
Journal of Medical Genetics 41, 523-528.

Wenzel, L., Berkowitz, R.S., Habbal, R, Newlands, E., Hancock, B., Goldstein, D.P., Seckl, M., Bernstein, M., Strickland, S. and Higgins, J. (2004)
Predictors of quality of life among long-term survivors of Gestational Trophoblastic Disease.
Journal of Reproductive Medicine 49, 589-594.

Wolff, C., Roy, S., Lewis, K.E., Schauerte, H., Joerg-Rauch, G., Kirn, A., Weiler, C., Geisler, R., Haffter, P. and Ingham, P.W. (2004)
iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo.
Genes and Development 18, 1565-76.

Zhu, Y.M., Webster, S.J., Flower, D. and Woll, P.J. (2004)
Interleukin-8/CXCL8 is a growth factor for human lung cancer cells.
British Journal of Cancer 91, 1970-1976.

Academic Unit of Ophthalmology and Orthoptics

Head of Department: Professor I G Rennie

Woodward, J.K., Sisley, K., Reeves, G., Nichols, C., Parsons, M.A., Mudhar, H., Rennie, I.G., (2004).
Evidence of macrophage and lymphocyte, but not dendritic cell, infiltration in posterior uveal melanomas, whilst cultured uveal melanomas demonstrate pluripotency by expressing CD68 and CD163.
Int J Exp Pathol 85, 35-43.