research publications

University of Sheffield

2005/6

DIVISION OF GENOMIC MEDICINE
YCR Director of Cancer Research: Professor B W Hancock

SECTION OF ONCOLOGY AND PATHOLOGY
(YCR Institute for Cancer Studies, Academic Unit of Clinical Oncology, Academic Unit of Pathology)

YCR Institute for Cancer Studies

Bryant, H.E., Schultz, N, Thomas, H.D., Parker, K.M., Flower, D., Lopez, E., Kyle, S., Meuth, M., Curtin, N.J., Helleday, T. (2005)
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Nature, 434, 913-7
Link to abstract of this publication

Srensen, C.S., Hansen, L.T., Dziegielewski, J., Syljusen, R.G., Lundin, C., Bartek, J., Helleday, T. (2005)
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Nature Cell Biology, 7(2), 195-201

Renglin Lindh, A., Rafii, S., Schultz, N., Cox, A., Helleday, T. (2006)
Mitotic defects in XRCC3 variants T241M and D213N and their relation to cancer susceptibility
Human Molecular Genetics, 15(7), 1217-1224

Saleh-Gohari, N., Bryant, H.E., Schultz, N., Parker, K.M., Cassel, T.N., Helleday, T. (2005)
Spontaneous homologous recombination is induced by collapsed replication forks that are caused by endogenous DNA single-strand breaks
Molecular and Cellular Biology, 25(16), 71587169

Lundin, C., Erixon, K., North, M., Walters, K., Jenssen, D., Goldman, A.S., Helleday, T. (2005)
Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks
Nucleic Acids Research, 33(12), 3799-811

Helleday, T., Bryant, H.E., Schultz, N. (2005)
Poly(ADP-ribose) polymerase (PARP-1) in homologous recombination and as a target for cancer therapy
Cell Cycle, 4(9) 1176-78

Catto, J.W.F., Azzouzi, A.-R., Rehman, I., Feeley, K.M., Cross, S.S., Amira, N. Fromont, G., Sibony, M., Cussenot, O., Meuth, M. and Hamdy, F.C. (2005)
Promoter hypermethylation is associated with tumor location, stage and subsequent progression in transitional cell carcinoma
J. Clin. Oncol. 23, 2903-2910


Academic Unit of Clinical Oncology

El-Helw, L., Coleman, R.E. (2005)
Reduced dose capecitabine is an effective and well-tolerated treatment in patients with metastatic breast cancer
The Breast, 14, 368-374

Coleman, R.E. (2005)
Bisphosphonates in breast cancer
Annals of Oncology, 16, 687-695

Coleman R.E., Major, P., Lipton, A., Brown, J.E., Lee, K-A., Smith, M., Saad, F., Zheng, M., Hei, Y.J., Seaman, J., Cook, R. (2005)
Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid
J. Clinical Oncology, 23(22), 4925-4935

Reed, S.D., Radeva, J.I., Glendenning, A., Coleman, R.E., Schulman, K.A. (2005)
Economic evaluation of zoledronic acid versus pamidronate for the prevention of skeletal-related events in metastatic breast cancer and multiple myeloma
American Journal of Clinical Oncology, 28(1), 8-16


Academic Unit of Pathology

Rachel M. Ryan, Jeffrey Green, and Claire E. Lewis (2005)
Use of bacteria in anti-cancer therapies
BioEssays 28:84-94

Claire Lewis and Craig Murdoch. (2005)
Macrophage responses to hypoxia
American Journal of Pathology; Vol. 167, 627-635, No. 3 September 2005

Craig Murdoch, Munitta Muthana, and Claire E. Lewis (2005)
Hypoxia regulates macrophage functions in inflammation
The Journal of Immunology, 6527-6263

Lewis CE and Pollard JW. (2006)
Distinct role of macrophages in different tumor microenvironments
Cancer Res. 66: 605-612


DIVISION OF CLINICAL SCIENCES (S)
Medical Physics and Medical Imaging

Hanney, M., Matthews, S., Lorenz, E., van Beek, E., Mitchell, S., Fleming, S., Vaughan, R. and Tindale, W.B. (2005)
Should gamma camera PET have a role in non-small cell lung cancer? A comparison of gamma camera PET, CT and histology
Nuclear Medicine Communications, 26, 285


DEPARTMENT OF BIOMEDICAL SCIENCE

Enver, T., Soneji, S., Joshi, C., Brown, J., Iborra, F., Orntoft, T., Thykjaer, T., Maltby, E., Smith, K., Dawud, R.A., Jones, M., Matin, M., Gokhale, P., Draper, J and Andrews, P.W. (2005)
Cellular differentiation hierarchies in normal and culture-adapted human embryonic stem cells
Human Molecular Genetics 14, 3129-3140

Andrews, P.W., Matin, M.M., Bahrami, A.R., Damjanov, I., Gokhale, P. and Draper, J.S. (2005)
Embryonic stem (ES) cells and embryonal carcinoma (EC) cells: opposite sides of the same coin
Biochemical Society Transactions 33, 1526-1530

Skotheim, R.I., Lind, G.E., Monni, O., Nesland, J.M., Abeler, V.M., Fossa, S.D., Duale, N., Brunborg, G., Kallioniemi, O., Andrews, P.W. and Lothe, R.A. (2005)
Differentiation of human embryonal carcinomas in vitro and in vivo reveals expression profiles relevant to normal development
Cancer Research 65, 5588-5598

Bahrami, A.R., Matin, M.M. and Andrews, P.W. (2005)
The CDK inhibitor p27 enhances neural differentiation in pluripotent NTERA2 human EC cells, but does not permit differentiation of 2102Ep nullipotent human EC cells
Mechanisms of Development 122, 1034-1042

Adamah, D.J.B., Gokhale, P.J., Eastwood, D.J., Rajpert de-Meyts, E., Goepel, J., Walsh, J.R., Moore, H.D. and Andrews, P.W. (2005)
Dysfunction of the mitotic:meiotic switch as a potential cause of neoplastic conversion of primordial gem cells
International Journal of Andrology 29, 219-227