research publications

University of Sheffield

2007/08


Faculty of Medicine
School of Medicine and Biomedical Sciences
Section of Oncology  

YCR Institute for Cancer Studies  


Cox, A., Dunning, A.M., Garcia-Closas, M. et al., on behalf of the Breast Cancer Association Consortium (2007)
A common coding variant in CASP8 is associated with breast cancer risk
Nature Genetics, 39(3): 352-358.  

Easton, D.F. et al. (2007 
Genome-wide association study identifies breast cancer susceptibility loci 
Nature, 447: 1087-1093 (the acknowledgements are online, see attached).  

Sanders, C.M. (2008)
A DNA binding activity in BPV initiator protein E1 required for melting duplex ori DNA but not processive helicase activity initiated on partially single-stranded DNAs
Nucleic Acids Res., 36: 1891-1899.  

Sanders, C.M., Kovalevskiy, O.V., Sizov, D., Lebedev, A.A., Isupov, M.N.,. Antson, A.A.  (2007)
Papillomavirus E1 helicase forms an asymmetric assembly in the absence of DNA and nucleotide cofactors 
Nucleic Acids Res., 35: 6451-6457.  

Roupret, M., Hupertan, V., Yates, D.R., Catto, J.W., Rehman, I., Meuth, M., Ricci, S.,, Lacave, R., Cancel-Tassin, G., de la Taille, A., Rozet, F., Cathelineau, X., Vallancien, G., Hamdy, F.C., Cussenot, O. (2007)
Molecular detection of localized prostate cancer using quantitative methylation-specific PCR on urinary cells obtained following prostate massage
Clin Cancer Res., 13: 1720-1725.  

Azzouzi, A.R., Catto, J.W., Rehman, I., Larre, S., Roupret, M., Feeley, K.M., Cussenot, O., Meuth, M., Hamdy, F.C. (2007)
Clinically localised prostate cancer is microsatellite stable
BJU Int., 99: 1031-5.  

Yates, D.R., Rehman, I., Abbod, M., Meuth, M., Cross, S.S., Linkens, D.A., Hamdy,  F.C., Catto, J.W.F. (2007)
Promoter hypermethylation identifies progression risk in bladder cancer 
Clin. Cancer Res., 13: 2046-53  

Rodriguez, R., Gagou, M.E., Meuth, M. (2008)
Apoptosis induced by replication inhibitors in Chk1 depleted cells is dependent upon the helicase cofactor Cdc45
Cell Death and Differ., 15: 889-898.  

Wen, Q., Scorah, J., Phear, G., Rodgers, G., Rodgers, S., Meuth, M. (2008)
A mutant allele of MRE11 found in mismatch repair deficient tumor cells suppresses the cellular response to DNA replication fork stress in a dominant negative manner
Mol. Biol. Cel,, 19: 1693-1705.  

Sleeth, K., et al. (2007)
RPA mediates recombination repair during replication stress and is displaced from DNA by checkpoint signalling in human cells
J. Mol Biol., Oct 12;373(1): 38-47.    


Academic Unit of Surgical Oncology

Bluff, J.E., Brown, N.J., Reed, M.W.R., Staton, C.A. (2008)
Tissue Factor, angiogenesis and tumour progression
Breast Cancer Research, 10: 204  

Balasubramanian, S.P., Cross, S.S., Globe, J., Cox, A., Brown, N.J., Reed, M.W. (2007)
Endostatin gene variation and protein levels in breast cancer susceptibility and severity
BMC Cancer, 7: 107-114   .


Academic Unit of Ophthalmology and Orthoptics

Canovas, D., Rennie, I.G., Nichols, C., Sisley, K. (2008).
Local environmental influences on uveal melanoma: The vitreous humor promotes uveal melanoma invasion, whilst the aqueous can be inhibitory
Cancer, 112: 1787-1794.  Published online 25.02.08  


Academic Unit of Pathology

Biswas, S.K., Sica, A., Lewis, C.E. (2008).
Plasticity of Macrophage Function during Tumor Progression: Regulation by Distinct Molecular Mechanisms
J. Immunol., 180: 2011-2017.  

De Palma, M., Murdoch, C., Venneri, M.A., Naldini, L., Lewis, C.E. (2007).
Tie2-expressing Monocytes: Regulation of Tumor Angiogenesis and Therapeutic Implications
Trends Immunol., 28: 545-50  

Lewis, C.E., De Palma, M., Naldini, L. (2007).  
Tie2-expressing Monocytes and Tumor Angiogenesis: Regulation by Hypoxia and Angiopoietin-2 
Cancer Res.,  67(18): 8429-32.  

Murdoch, C., Tazzyman, S., Webster, S., Lewis, C.E. (2007).
Expression of Tie-2 by human monocytes and their responses to angiopoietin-2
J. Immunol., 178: 7405-11.  


Department of Biomedical Sciences  

Baker, D.E.C., Harrison, N.J., Maltby, E., Smith, K., Moore, H.D., Shaw, P.J., Heath, P.R., Holden, H., Andrews, P.W.  (2007) 
Adaptation to culture of human embryonic stem cells and oncogenesis in vivo 
Nature Biotechnology, 25: 207 - 215.  

Harrison, N.J., Baker, D., Andrews, P.W.  2007 
Culture adaptation of embryonic stem cells echoes germ cell malignancy 
Int J Androl., 30: 275-281. [Epub ahead of print May 7].