programme of research

University of York  

2007/08


Department of Biology
Mammalian DNA Replication Research Group  

Principal Investigator: Dr. Dawn Coverley    

F.A. Rahman              
K. Roper                     
D. Coverley  
Functional consequences of cancer-associated Ciz1 splice variant expression

N.Copeland                
D. Coverley                 
Functional validation of the interaction between Ciz1 and NDHII  

N.Copeland                
D. Coverley    
Functional analysis of Ciz1-cyclin/CDK interactions     


YCR Cancer Research Unit
Director: Professor N. J. Maitland  

A.T. Collins,                
P. Berry,
K. Hyde,
N.J. Maitland  
Stem cell hierarchies in human prostate tumours

F. Frame,                    
S. Hager,                     
J. Burns,
A.T. Collins,
N.J. Maitland  
Development of lentiviral vectors to track the lineage and differentiation of prostate cancer stem cells

A.T. Collins,                 
P.A. Berry    
The role of androgen signalling in the regulation of human prostatic stem cell differentiation  

J.E. Burns,                   
H.F. Walker,               
N.J. Maitland 
Development of lentiviral vectors to express suicide genes in prostate cancer cells  

S. Swift,                       
J. Burns,                      
N.J. Maitland
Retargeting of baculoviral gene therapy vectors to infect the prostate 


YCR P53 Research Unit
Director: Professor J. Milner    

S.U. Ahmed,               
J. Milner
Basal functions of JNK1 and JNK2 in cancer  

S.J. Allison,               
J. Milner    
The roles of SIRTUINS in cancer

J.R. Ford,                 
J. Milner      
Comparison of basal versus stress-induced SIRT1 and p53

M. Jiang,                  
J. Milner    
Construction of SIRT1 expression vectors

C. Lynch,                 
J. Milner 
P53 gene dosage, SIRT1 and chromatin interactions 

L.J. Warnock,         
R.E.Adamson,
S.A. Raines,
J. Milner          
How post-translational modifications influence p53 functions